Details of Disease

General Information of Disease (ID: DIS9G09S)

Disease Name	Viral encephalitis
Synonyms	viral encephalitis; Viruses encephalitis; Viruses caused encephalitis
Disease Class	1C80: Viral encephalitis
Definition	Encephalitis resulting from viral infection.\|Editor note: we place the Orphanet class here as it is implicitly viral
Disease Hierarchy	DISH6045: Viral infection of central nervous system DISLD1RL: Encephalitis DISDI77C: Primary viral infectious disease DISTC30O: Infectious encephalitis DISEM33Q: Infectious disease DIS9G09S: Viral encephalitis
ICD Code	ICD-11 ICD-11: 1C80 Expand ICD-11 '1C8Z Expand ICD-10 'A80-A89; 'A81; 'A81.8; 'A81.9; 'A83; 'A83.8; 'A83.9; 'A84.8; 'A84.9; 'A85.0; 'A88; 'A88.1; 'A88.8; 'A89; 'G05.1
Disease Identifiers	MONDO ID MONDO_0006009 MESH ID D018792 UMLS CUI C0243010 MedGen ID 116719 HPO ID HP:0033993 Orphanet ID 98252 SNOMED CT ID 34476008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
OTK18 TF mabs	DMOYJAK	Investigative	Monoclonal antibody	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADRB2	TTG8ZWP	moderate	Biomarker	[2]
OPRM1	TTKWM86	moderate	Biomarker	[2]
IFNAR2	TTMQB37	Strong	Biomarker	[3]
KLK8	TTH5MRS	Strong	Biomarker	[4]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SETD3	OTO5RAU2	moderate	Biomarker	[5]
IVNS1ABP	OTYHL4I7	Strong	Biomarker	[6]
KLHL2	OT1NG8V7	Strong	Biomarker	[7]
KPNA3	OTLI3TM2	Strong	Biomarker	[8]
KPNA4	OTP0EX18	Strong	Biomarker	[8]
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References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	-Adrenergic receptor gene expression in HIV-associated neurocognitive impairment and encephalitis: implications for MOR-1K subcellular localization.J Neurovirol. 2016 Dec;22(6):866-870. doi: 10.1007/s13365-016-0464-1. Epub 2016 Jul 11.
3	Type I Interferon Receptor Signaling of Neurons and Astrocytes Regulates Microglia Activation during Viral Encephalitis.Cell Rep. 2018 Oct 2;25(1):118-129.e4. doi: 10.1016/j.celrep.2018.09.003.
4	Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response.Biol Chem. 2014 Sep;395(9):1063-73. doi: 10.1515/hsz-2014-0141.
5	Enterovirus pathogenesis requires the host methyltransferase SETD3.Nat Microbiol. 2019 Dec;4(12):2523-2537. doi: 10.1038/s41564-019-0551-1. Epub 2019 Sep 16.
6	Structural Study of the C-Terminal Domain of Nonstructural Protein 1 from Japanese Encephalitis Virus.J Virol. 2018 Mar 14;92(7):e01868-17. doi: 10.1128/JVI.01868-17. Print 2018 Apr 1.
7	A Protective Role for Interleukin-1 Signaling during Mouse Adenovirus Type 1-Induced Encephalitis.J Virol. 2017 Jan 31;91(4):e02106-16. doi: 10.1128/JVI.02106-16. Print 2017 Feb 15.
8	Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-B.J Virol. 2017 Mar 29;91(8):e00039-17. doi: 10.1128/JVI.00039-17. Print 2017 Apr 15.