Details of Disease | DrugMAP

General Information of Disease (ID: DIS9WGEZ)

Disease Name	Obsolete hereditary persistence of alpha-fetoprotein
Synonyms	HPAFP; ALPHA-fetoprotein, hereditary persistence OF; hereditary persistence of alpha-fetoprotein
Definition	OBSOLETE. Hereditary persistence of alpha-fetoprotein is a benign genetic condition characterized by persistence of high alpha-fetoprotein (AFP) levels throughout life, with no associated clinical disability and thus no need for specific therapy\|This is a biological anomaly and not a disease.
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DIS9WGEZ: Obsolete hereditary persistence of alpha-fetoprotein

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AFP	TTCFEA1	Supportive	Autosomal dominant	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AFP	OT9GG3ZI	Supportive	Autosomal dominant	[1]
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References

1	A G-->A substitution in an HNF I binding site in the human alpha-fetoprotein gene is associated with hereditary persistence of alpha-fetoprotein (HPAFP). Hum Mol Genet. 1993 Apr;2(4):379-84. doi: 10.1093/hmg/2.4.379.