Details of Disease

General Information of Disease (ID: DISA474V)

• Disease Name: Vulvar intraepithelial neoplasia
• Synonyms: squamous vulvar intraepithelial neoplasia; VIN; intraepithelial neoplasia of the vulva; vulval intraepithelial neoplasia; intraepithelial neoplasia of vulva; vulvar intraepithelial tumor; vulva intraepithelial neoplasia; vulvar intraepithelial tumour
• Disease Class: 2E67: Genital organ in situ carcinoma
• Definition: Intraepithelial neoplasia of the vulvar squamous epithelium. There is no evidence of invasion. This category includes vulvar high grade squamous intraepithelial lesion and vulvar intraepithelial neoplasia, differentiated type.
• Disease Hierarchy:
  DISGEXCB: Vulvar squamous neoplasm
  DISA474V: Vulvar intraepithelial neoplasia
• ICD Code:
  ICD-11: ICD-11: 2E67.10
  ICD-10: ICD-10: N90.1, N90.2
  Expand ICD-11: '2E67.10
  Expand ICD-10: 'N90.1; 'N90.2
• Disease Identifiers:
  MONDO ID: MONDO_0005198
  UMLS CUI: C0346210
  MedGen ID: 91093
  HPO ID: HP:0032202
  Orphanet ID: 137583
  SNOMED CT ID: 399382009

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Omiganan	DM7UF9M	Phase 3	NA	[1]
VGX-3100	DMMQ2U9	Phase 3	NA	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARHGEF1	OTXU4HBW	Strong	Biomarker	[3]
KRT10	OTSVRD3Q	Strong	Altered Expression	[4]
SEC62	OTCWEL5F	Strong	Biomarker	[5]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Vulvar lichen sclerosus and squamous cell carcinoma: a cohort, case control, and investigational study with historical perspective; implications for chronic inflammation and sclerosis in the development of neoplasia.Hum Pathol. 1998 Sep;29(9):932-48. doi: 10.1016/s0046-8177(98)90198-8.
• [4] Major histocompatibility complex and human papillomavirus type 16 E7 expression in high-grade vulvar lesions.Hum Pathol. 1993 May;24(5):519-24. doi: 10.1016/0046-8177(93)90164-c.
• [5] Sec62/Ki67 and p16/Ki67 dual-staining immunocytochemistry in vulvar cytology for the identification of vulvar intraepithelial neoplasia and vulvar cancer: a pilot study.Arch Gynecol Obstet. 2019 Mar;299(3):825-833. doi: 10.1007/s00404-018-5021-0. Epub 2019 Jan 4.