Details of Disease

Disease Name

Secondary progressive multiple sclerosis

secondary-progressive MS; SPMS

Definition

A multiple sclerosis with a clinical course characterized by a progressive accumulation of neurological disability, independent of relapses, following an initial relapsing-remitting (RR) phase.

Disease Hierarchy

DIS9JZ35: Chronic progressive multiple sclerosis

DISAJTO1: Secondary progressive multiple sclerosis

Disease Identifiers

MONDO ID

MONDO_0000450

MESH ID

D020528

UMLS CUI

C0751965

MedGen ID

155969

SNOMED CT ID

425500002

General Information of Disease (ID: DISAJTO1)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FP-187	DMWZO21	Phase 2	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RGMA	TTURJV4	Strong	Biomarker	[2]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
TGM6	DEUWCVD	Strong	Altered Expression	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CCL26	OT2B7HR9	Strong	Biomarker	[4]
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References

1	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2	Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.Cell Death Dis. 2018 Oct 17;9(11):1061. doi: 10.1038/s41419-018-1118-4.
3	Transglutaminase-6 is an autoantigen in progressive multiple sclerosis and is upregulated in reactive astrocytes.Mult Scler. 2017 Nov;23(13):1707-1715. doi: 10.1177/1352458516684022. Epub 2016 Dec 22.
4	CCL26 and CCR3 are associated with the acute inflammatory response in the CNS in experimental autoimmune encephalomyelitis.J Neuroimmunol. 2019 Aug 15;333:576967. doi: 10.1016/j.jneuroim.2019.576967. Epub 2019 May 16.