Details of Disease | DrugMAP

General Information of Disease (ID: DISAT156)

Disease Name	Tooth agenesis, selective, 7
Synonyms	tooth agenesis caused by mutation in LRP6; STHAG7; LRP6 tooth agenesis; tooth agenesis, selective, 7; STHAG7; tooth agenesis, selective, 7; tooth agenesis, selective, type 7
Definition	Any tooth agenesis in which the cause of the disease is a mutation in the LRP6 gene.
Disease Hierarchy	DIS1PWC7: Tooth agenesis DISAT156: Tooth agenesis, selective, 7
Disease Identifiers	MONDO ID MONDO_0014749 UMLS CUI C4225231 OMIM ID 616724 MedGen ID 899184

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LRP6	TTSXOWE	Strong	Autosomal dominant	[1]
LRP6	TTSXOWE	Strong	Genetic Variation	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LRP6	OTM7PSUR	Strong	Autosomal dominant	[1]
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References

1	Loss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia. Am J Hum Genet. 2015 Oct 1;97(4):621-6. doi: 10.1016/j.ajhg.2015.08.014. Epub 2015 Sep 17.