Details of Disease

General Information of Disease (ID: DISB13HR)

Disease Name	Melioidosis
Synonyms	Burkholderia pseudomallei infection; B pseudomallei infection; Whitmore disease; acute and fulminating melioidosis; pseudoglanders; Burkholderia pseudomallei infectious disease; Whitmore's disease; subacute and chronic melioidosis; Burkholderia pseudomallei disease or disorder; Burkholderia pseudomallei caused disease or disorder; Nightcliff gardener's disease
Disease Class	1C42: Melioidosis
Definition	An infection that is caused by Burkholderia pseudomallei, which is found in soil and water; symptoms vary widely, but most commonly include fever, cough, pneumonia, arthralgia, myalgia, and skin ulceration.
Disease Hierarchy	DIS95DMT: Burkholderia infectious disease DIS8ZVFW: Primary bacterial infectious disease DISEM33Q: Infectious disease DISB13HR: Melioidosis
ICD Code	ICD-11 ICD-11: 1C42 Expand ICD-11 '1C42 Expand ICD-10 'A24; 'A24.1; 'A24.2; 'A24.3; 'A24.4
Disease Identifiers	MONDO ID MONDO_0017775 MESH ID D008554 UMLS CUI C0025229 MedGen ID 44346 Orphanet ID 31202 SNOMED CT ID 428111003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ARV-1801	DMUMFDU	Phase 2	Small molecule	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CASP6	TTKW4ML	Strong	Altered Expression	[2]
HRC	TTR4FKD	Strong	Biomarker	[3]
RNF34	TTEWDK1	Strong	Biomarker	[4]
TLR1	TTW14D0	Strong	Genetic Variation	[5]
PDE7A	TT1BC3A	Definitive	Biomarker	[6]
PRMT1	TTVOJAI	Definitive	Biomarker	[6]
SLC46A1	TTY8Z2E	Definitive	Biomarker	[6]
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⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GSDMD	OTH39BKI	Strong	Biomarker	[7]
HSD17B6	OTSB55D2	Strong	Biomarker	[8]
NBEAL1	OTLJ11N3	Strong	Biomarker	[9]
NLRC4	OTAIA3NA	Strong	Genetic Variation	[10]
RHOF	OTPA3F8Q	Strong	Biomarker	[4]
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References

1	ClinicalTrials.gov (NCT05105035) A Randomized, Double-Blind, Placebo-Controlled, Exploratory Study to Assess the Efficacy, Safety and Tolerability of Oral ARV-1801 Given in Combination With Intravenous Ceftazidime or Meropenem for Intensive Phase Therapy of Melioidosis in Hospitalized Patients. U.S.National Institutes of Health.
2	Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.PLoS One. 2017 Jul 7;12(7):e0180203. doi: 10.1371/journal.pone.0180203. eCollection 2017.
3	The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.Infect Immun. 2011 Apr;79(4):1512-25. doi: 10.1128/IAI.01218-10. Epub 2011 Feb 7.
4	Melioidosis in patients with suspected tuberculosis in Cambodia: a single-center cross-sectional study.Int J Tuberc Lung Dis. 2018 Dec 1;22(12):1481-1485. doi: 10.5588/ijtld.17.0294.
5	Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis.Emerg Microbes Infect. 2019;8(1):282-290. doi: 10.1080/22221751.2019.1575172.
6	Distinct classes and subclasses of antibodies to hemolysin co-regulated protein 1 and O-polysaccharide and correlation with clinical characteristics of melioidosis patients.Sci Rep. 2019 Sep 27;9(1):13972. doi: 10.1038/s41598-019-48828-4.
7	Gasdermin D Protects from Melioidosis through Pyroptosis and Direct Killing of Bacteria.J Immunol. 2019 Jun 15;202(12):3468-3473. doi: 10.4049/jimmunol.1900045. Epub 2019 Apr 29.
8	Virulence of the Melioidosis Pathogen Burkholderia pseudomallei Requires the Oxidoreductase Membrane Protein DsbB.Infect Immun. 2018 Apr 23;86(5):e00938-17. doi: 10.1128/IAI.00938-17. Print 2018 May.
9	Soil characteristics influencing the spatial distribution of melioidosis in Far North Queensland, Australia.Epidemiol Infect. 2018 Sep;146(12):1602-1607. doi: 10.1017/S0950268818001188. Epub 2018 Jul 4.
10	NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.PLoS Negl Trop Dis. 2014 Sep 18;8(9):e3178. doi: 10.1371/journal.pntd.0003178. eCollection 2014 Sep.