Details of Disease | DrugMAP

General Information of Disease (ID: DISBEWBO)

Disease Name	Autosomal dominant nonsyndromic hearing loss 10
Synonyms	autosomal dominant nonsyndromic deafness caused by mutation in EYA4; autosomal dominant nonsyndromic deafness 10; EYA4 autosomal dominant nonsyndromic deafness; deafness, autosomal dominant type 10; deafness, autosomal dominant 10; autosomal dominant nonsyndromic deafness type 10; autosomal dominant deafness 10; DFNA10; autosomal dominant nonsyndromic hearing loss 10
Definition	Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the EYA4 gene.
Disease Hierarchy	DISYC1G0: Autosomal dominant nonsyndromic hearing loss DISBEWBO: Autosomal dominant nonsyndromic hearing loss 10
Disease Identifiers	MONDO ID MONDO_0011031 MESH ID C563354 UMLS CUI C1832476 OMIM ID 601316 MedGen ID 321966

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TECTA	OT5E0NE2	Disputed	Biomarker	[1]
EYA4	OTINGR3Z	Strong	Autosomal dominant	[2]
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References

1	Research progress in pathogenic genes of hereditary non-syndromic mid-frequency deafness.Front Med. 2016 Jun;10(2):137-42. doi: 10.1007/s11684-016-0449-8. Epub 2016 May 3.
2	Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus. Hum Mol Genet. 2001 Feb 1;10(3):195-200. doi: 10.1093/hmg/10.3.195.