Details of Disease

General Information of Disease (ID: DISCT6PQ)

• Disease Name: Obsolete hereditary late onset Parkinson disease
• Definition: These two terms are equivalent: 'late-onset Parkinson disease' is a child of the OMIM phenotypic series 'Parkinson disease', which is an inherited form of the disease, so the class 'late-onset Parkinson disease' inherits the hereditary form.
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISCT6PQ: Obsolete hereditary late onset Parkinson disease

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
VPS35	OT9FYHRX	Supportive	Autosomal dominant	[1]
DNAJC13	OTYAVVJ6	Supportive	Autosomal dominant	[3]
LRRK2	OTLS7C99	Supportive	Autosomal dominant	[1]
SNCA	OTPWC1MR	Supportive	Autosomal dominant	[2]

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
LRRK2	TTK0FEA	Supportive	Autosomal dominant	[1]
SNCA	TT08OSU	Supportive	Autosomal dominant	[2]

References

• [1] Role of mendelian genes in "sporadic" Parkinson's disease. Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S66-70. doi: 10.1016/S1353-8020(11)70022-0.
• [2] The Ala53Thr mutation in the alpha-synuclein gene in a Korean family with Parkinson disease. Clin Genet. 2007 May;71(5):471-3. doi: 10.1111/j.1399-0004.2007.00781.x.
• [3] DNAJC13 mutations in Parkinson disease. Hum Mol Genet. 2014 Apr 1;23(7):1794-801. doi: 10.1093/hmg/ddt570. Epub 2013 Nov 11.