Details of Disease | DrugMAP

General Information of Disease (ID: DISCVLOG)

Disease Name	Atrial fibrillation, familial, 3
Synonyms	ATFB3; familial atrial fibrillation caused by mutation in KCNQ1; atrial fibrillation, familial, 3; KCNQ1 familial atrial fibrillation; atrial fibrillation, familial, type 3
Definition	Any familial atrial fibrillation in which the cause of the disease is a mutation in the KCNQ1 gene.
Disease Hierarchy	DISL4AGF: Familial atrial fibrillation DISCVLOG: Atrial fibrillation, familial, 3
Disease Identifiers	MONDO ID MONDO_0011857 MESH ID C563817 UMLS CUI C1837014 OMIM ID 607554 MedGen ID 373232

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KCNQ1	TT846HF	moderate	Biomarker	[1]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
KCNQ1	DTYE3RN	Strong	Autosomal dominant	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KCNQ1	OT8SPJNX	Strong	Autosomal dominant	[2]
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References

1	Emerging therapeutic targets in the short QT syndrome.Expert Opin Ther Targets. 2018 May;22(5):439-451. doi: 10.1080/14728222.2018.1470621.
2	Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation. Heart Rhythm. 2009 Aug;6(8):1146-53. doi: 10.1016/j.hrthm.2009.04.015. Epub 2009 Apr 15.