Details of Disease

General Information of Disease (ID: DISDI464)

Disease Name	Trichotillomania
Synonyms	TTM; trichotillomania; trichotillomania, multifactorial
Disease Class	6B25: Body-focused behaviour disorder
Definition	A disorder characterized by repetitive pulling out of one's hair resulting in noticeable hair loss; the individual experiences a rising subjective sense of tension before pulling out the hair and a sense of gratification or relief when pulling out the hair.
Disease Hierarchy	DISYKSRF: Genetic disease DISRIYJ5: Impulse control disorder DISDI464: Trichotillomania
ICD Code	ICD-11 ICD-11: 6B25.0
Disease Identifiers	MONDO ID MONDO_0013189 MESH ID D014256 UMLS CUI C0040953 OMIM ID 613229 MedGen ID 21654 HPO ID HP:0012167 SNOMED CT ID 17155009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SXC-2023	DMZV27P	Phase 2	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SLITRK1	OT1QQ7FR	Limited	Unknown	[2]
HOXB8	OTKHOD17	Strong	Genetic Variation	[3]
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References

1	ClinicalTrials.gov (NCT03797521) A Study in Patients With Trichotillomania (TTM). U.S. National Institutes of Health.
2	SLITRK1 mutations in trichotillomania. Mol Psychiatry. 2006 Oct;11(10):887-9. doi: 10.1038/sj.mp.4001898.
3	Corticostriatal circuit defects in Hoxb8 mutant mice.Mol Psychiatry. 2018 Sep;23(9):1868-1877. doi: 10.1038/mp.2017.180. Epub 2017 Sep 26.