Details of Disease

General Information of Disease (ID: DISE28DD)

Disease Name	Pouchitis
Disease Class	N.A.: Pouchitis
Definition	Acute inflammation in the intestinal mucosa of the continent ileal reservoir (or pouch) in patients who have undergone ileostomy and restorative proctocolectomy (proctocolectomy, restorative).
Disease Hierarchy	DISF979Y: Small intestine disorder DISE28DD: Pouchitis
ICD Code	ICD-11 ICD-11: N.A.
Disease Identifiers	MONDO ID MONDO_0005312 MESH ID D019449 UMLS CUI C0376620 MedGen ID 138232 Orphanet ID 217067

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
EXE-346	DMYQB63	Phase 2	Live biotherapeutic	[1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TNFSF15	TTEST6I	Limited	Genetic Variation	[2]
EGLN2	TTMHFRY	Strong	Biomarker	[3]
IRAK3	TTBPJOK	Strong	Genetic Variation	[4]
------------------------------------------------------------------------------------

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ITLN1	OT7ZLJVV	Strong	Genetic Variation	[2]
JTB	OT314JB6	Strong	Altered Expression	[5]
MTFMT	OT1OIVJL	Strong	Biomarker	[6]
------------------------------------------------------------------------------------

References

1	Clinical pipeline report, company report or official report of ExeGi Pharma
2	A Polymorphism in Interleukin-1 Gene Is Associated with the Development of Pouchitis in Japanese Patients with Ulcerative Colitis.Digestion. 2021;102(3):489-498. doi: 10.1159/000503283. Epub 2019 Oct 31.
3	Prolyl Hydroxylase Inhibition Mitigates Pouchitis.Inflamm Bowel Dis. 2020 Jan 6;26(2):192-205. doi: 10.1093/ibd/izz218.
4	Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis.World J Gastroenterol. 2005 Dec 14;11(46):7323-9. doi: 10.3748/wjg.v11.i46.7323.
5	Faecal Proteases from Pouchitis Patients Activate Protease Activating Receptor-2 to Disrupt the Epithelial Barrier.J Crohns Colitis. 2019 Dec 10;13(12):1558-1568. doi: 10.1093/ecco-jcc/jjz086.
6	Faecal Microbiota Transplantation for Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.J Crohns Colitis. 2017 Oct 1;11(10):1180-1199. doi: 10.1093/ecco-jcc/jjx063.