Details of Disease

Disease Name

B-cell small lymphocytic lymphoma

Disease Class

2A82: Mature B-cell leukaemia

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISETZ8S: B-cell small lymphocytic lymphoma

ICD-11

ICD-11: 2A82.0

ICD-10

ICD-10: C83.0, C91.1

Disease Identifiers

MONDO ID

MONDO_0003864

UMLS CUI

C1302547

MedGen ID

224906

General Information of Disease (ID: DISETZ8S)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CD19.CAR-aNKT cells	DMMO2EJ	Phase 1	CAR T Cell Therapy	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IKZF2	TTKT5NV	Strong	Biomarker	[2]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC35B2	DT81RKJ	Strong	Altered Expression	[3]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDR2	OTD3ZJST	Strong	Genetic Variation	[4]
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References

1	ClinicalTrials.gov (NCT03774654) CD19.CAR Allogeneic NKT for Patients With Relapsed or Refractory B-Cell Malignancies (ANCHOR)
2	Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial.Pharm Res. 2019 May 1;36(7):93. doi: 10.1007/s11095-019-2605-8.
3	Chronic lymphocytic leukemia/small lymphocytic lymphoma with cyclin D1 positive proliferation centers do not have CCND1 translocations or gains and lack SOX11 expression.Am J Clin Pathol. 2012 Jul;138(1):132-9. doi: 10.1309/AJCPIVKZRMPF93ET.
4	Analysis of the immunoglobulin heavy chain gene variable region of 101 cases with peripheral B cell neoplasms and B cell chronic lymphocytic leukemia in the japanese population.Pathol Int. 1999 Jul;49(7):595-600. doi: 10.1046/j.1440-1827.1999.00911.x.