Details of Disease

General Information of Disease (ID: DISFW74P)

Disease Name	Stress urinary incontinence
Synonyms	stress incontinence - female; female urinary stress incontinence
Disease Class	MF50: Abnormal micturition
Definition	The involuntary loss of urine in females secondary to insufficient strength of the pelvic floor muscles; this can result from physical changes following pregnancy and childbirth, or as a response to a decrease in estrogen during menopause.
Disease Hierarchy	DISTVIQI: Bladder disease DISFW74P: Stress urinary incontinence
ICD Code	ICD-11 ICD-11: MF50.20 ICD-10 ICD-10: N39, N39.3 Expand ICD-11 'MF50.20 Expand ICD-10 'N39; 'N39.3
Disease Identifiers	MONDO ID MONDO_0004160 MESH ID D014550 UMLS CUI C0038437 MedGen ID 21346 HPO ID HP:0010992 SNOMED CT ID 60241006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Duloxetine	DM9BI7M	Approved	Small molecular drug	[1]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
RCD-1	DM1ATGY	Preclinical	NA	[2]
------------------------------------------------------------------------------------

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
A-204176	DMPEJ4O	Terminated	NA	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RGS2	TTKB7T3	Strong	Biomarker	[4]
------------------------------------------------------------------------------------

References

1	Duloxetine FDA Label
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800039782)
3	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013646)
4	Molecular mechanisms related to parturition-induced stress urinary incontinence.Eur Urol. 2009 May;55(5):1213-22. doi: 10.1016/j.eururo.2008.02.027. Epub 2008 Mar 18.