Details of Disease

General Information of Disease (ID: DISG8CCO)

• Disease Name: Ischemia-reperfusion injury
• Disease Class: DB98: Liver vascular disorder
• Definition: Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury.
• Disease Hierarchy:
  DISKB4RK: Injury
  DISG8CCO: Ischemia-reperfusion injury
• ICD Code:
  ICD-11: ICD-11: DB98.B
  ICD-10: ICD-10: I00-I99

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetylcysteine	DMWSXI4	Approved	Small molecular drug	[1]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[2]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Reparixin	DMVBA7I	Phase 3	Small molecular drug	[4]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PS-519	DMI0WHC	Terminated	NA	[5]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Acetylcysteine FDA Label
• [2] Methylprednisolone FDA Label
• [3] Prednisolone FDA Label
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8498).
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009964)