Details of Disease | DrugMAP

General Information of Disease (ID: DISGCLSK)

Disease Name	Brunner syndrome
Synonyms	BRNRS; antisocial behavior, susceptibility to; monoamine oxidase A deficiency; Brunner syndrome, X-linked recessive; Brunner syndrome; antisocial behavior, X-linked recessive
Definition	Monoamine oxidase-A deficiency is a very rare recessive X-linked biogenic amine metabolism disorder characterized clinically by mild intellectual deficit, impulsive aggressiveness, and sometimes violent behavior and presenting from childhood.
Disease Hierarchy	DISFWXCM: Inborn disorder of amino acid metabolism DISHZGSA: X-linked recessive disease DISJ5YRX: Inborn disorder of neurotransmitter metabolism and transport DISGCLSK: Brunner syndrome
Disease Identifiers	MONDO ID MONDO_0010379 MESH ID C563156 UMLS CUI C0796275 OMIM ID 300615 MedGen ID 208683 Orphanet ID 3057 SNOMED CT ID 718210003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MAOA	TT3WG5C	Definitive	Biomarker	[1]
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This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MAOA	DERE4TU	Definitive	X-linked	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MAOA	OT8NIWMQ	Definitive	X-linked	[2]
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References

1	New insights into Brunner syndrome and potential for targeted therapy.Clin Genet. 2016 Jan;89(1):120-7. doi: 10.1111/cge.12589. Epub 2015 Apr 19.
2	Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.