Details of Disease

General Information of Disease (ID: DISGXN3Z)

• Disease Name: Herpes simplex encephalitis, susceptibility to, 4
• Synonyms: IIAE6; encephalopathy, acute, infection-induced (HERPES-specific), susceptibility to, 6; encephalopathy, acute, infection-induced (Herpes-specific), susceptibility to, 6; encephalopathy, acute, infection-induced, susceptibility to, 6; herpes simplex encephalitis, susceptibility to, 4; TICAM1 herpes simplex encephalitis; Herpes simplex encephalitis, susceptibility to, type 4; herpes simplex encephalitis caused by mutation in TICAM1
• Definition: A Mendelian susceptibility or predisposition to herpes simplex infection induced encephalitis in which the cause of the diseas is a mutation in the TICAM1 gene.
• Disease Hierarchy:
  DISIYKJL: Hereditary predisposition to infections
  DIS98MYE: Inherited disease susceptibility
  DISGXN3Z: Herpes simplex encephalitis, susceptibility to, 4
• Disease Identifiers:
  MONDO ID: MONDO_0013921
  UMLS CUI: C3553869
  OMIM ID: 614850
  MedGen ID: 766783

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
TICAM1	TT2GQT6	Strong	Autosomal recessive	[1]
TICAM1	TT2GQT6	Strong	Biomarker	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TICAM1	OTK6Y1HK	Strong	Autosomal recessive	[1]

References

• [1] Age-dependent Mendelian predisposition to herpes simplex virus type 1 encephalitis in childhood. J Pediatr. 2010 Oct;157(4):623-9, 629.e1. doi: 10.1016/j.jpeds.2010.04.020. Epub 2010 May 31.
• [2] Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.Genes Immun. 2015 Dec;16(8):552-66. doi: 10.1038/gene.2015.46. Epub 2015 Oct 29.