Details of Disease

General Information of Disease (ID: DISHMPS5)

• Disease Name: T-cell immunodeficiency
• Synonyms: T lymphocyte deficiency; T-lymphocyte immunodeficiency; T-lymphocyte deficiency (finding); T-cell immunodeficiency
• Definition: A broad classification of disorders that affect the cell-mediated aspect of the immune response. Circulating numbers of T lymphocytes are decreased or ineffective.
• Disease Hierarchy:
  DIS093I0: Immunodeficiency
  DISHMPS5: T-cell immunodeficiency
• Disease Identifiers:
  MONDO ID: MONDO_0003780
  UMLS CUI: C1274233
  MedGen ID: 226894
  SNOMED CT ID: 402792003

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD3E	TTZAT79	moderate	Biomarker	[1]
LRRC32	TT0FAYT	Strong	Biomarker	[2]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SIPA1	OTXY5RXC	moderate	Biomarker	[3]
SMARCAL1	OTTKXLUZ	Definitive	Genetic Variation	[4]

References

• [1] Over-expression of CD3 epsilon transgenes blocks T lymphocyte development.Int Immunol. 1995 Mar;7(3):435-48. doi: 10.1093/intimm/7.3.435.
• [2] Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency.AIDS Res Hum Retroviruses. 2013 Apr;29(4):641-51. doi: 10.1089/aid.2012.0322. Epub 2013 Feb 1.
• [3] Rap1 and SPA-1 in hematologic malignancy.Trends Mol Med. 2004 Aug;10(8):401-8. doi: 10.1016/j.molmed.2004.06.004.
• [4] Eltrombopag (thrombopoietin-receptor agonist) and plasmapheresis as rescue therapy of acute post-renal transplant immune thrombocytopenia in a child with Schimke immuno-osseous dysplasia-case report.Pediatr Transplant. 2016 Dec;20(8):1148-1151. doi: 10.1111/petr.12828. Epub 2016 Sep 26.