Details of Disease | DrugMAP

General Information of Disease (ID: DISHSSMC)

Disease Name	Spermatogenic failure 3
Synonyms	SPGF3; azoospermia caused by mutation in SLC26A8; spermatogenic failure type 3; spermatogenic failure 3; SLC26A8 azoospermia
Definition	Any azoospermia in which the cause of the disease is a mutation in the SLC26A8 gene.
Disease Hierarchy	DIS3D1AI: Spermatogenic failure DISHSSMC: Spermatogenic failure 3
Disease Identifiers	MONDO ID MONDO_0011720 UMLS CUI C4721889 OMIM ID 606766 MedGen ID 1648302

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SLC26A8	OTNCW8RJ	Limited	Autosomal dominant	[1]
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References

1	The testis anion transporter 1 (Slc26a8) is required for sperm terminal differentiation and male fertility in the mouse. Hum Mol Genet. 2007 Aug 1;16(15):1783-93. doi: 10.1093/hmg/ddm117. Epub 2007 May 20.