Details of Disease

General Information of Disease (ID: DISIFBM2)

• Disease Name: Smoking dependence
• Disease Class: 6C4A: Nicotine use disorder
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISIFBM2: Smoking dependence
• ICD Code:
  ICD-11: ICD-11: 6C4A.2
  ICD-10: ICD-10: F17.2
  ICD-9: ICD-9: 292
  Expand ICD-9: 292

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Bupropion	DM5PCS7	Approved	Small molecular drug	[1]
Tubocurarine	DMBZIVP	Approved	Small molecular drug	[2]
Varenicline	DMMUOLJ	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
X-22	DM7C0FT	Phase 2	NA	[4]
ARD-1600	DM9JJKF	Phase 1	NA	[5]
PF-05402536	DMQYZM8	Phase 1	NA	[6]
SEL-068	DMD28Q5	Phase 1	NA	[7]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2294).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5459).
• [4] Clinical pipeline report, company report or official report of 22nd Century Group.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027254)
• [6] ClinicalTrials.gov (NCT01672645) A Study to Assess the Safety and Tolerability of Different Doses of PF-05402536 and PF-06413367 in Healthy Adult Smokers.. U.S. National Institutes of Health.
• [7] ClinicalTrials.gov (NCT01478893) Safety and Pharmacodynamics of SEL-068 Vaccine in Smokers and Non-Smokers. U.S. National Institutes of Health.