Details of Disease

General Information of Disease (ID: DISIVD4P)

• Disease Name: Essential hypertension, genetic
• Synonyms: EHT; hypertension, salt-sensitive essential, susceptibility to; hypertension, essential, susceptibility to, 1; hypertension, essential; hypertension, essential, susceptibility to; hypertension, essential, susceptibility to, 6; hypertension, essential, susceptibility to, 2; hypertension, susceptibility to; hypertension, essential, susceptibility to, 3; hypertension, essential, susceptibility to, 4; hypertension, essential, susceptibility to, 5; hypertension, essential, salt-sensitive; genetic essential hypertension; blood pressure regulation QTL
• Definition: An instance of essential hypertension that is caused by a modification of the individual's genome.
• Disease Hierarchy:
  DISYKSRF: Genetic disease
  DIS7WI98: Essential hypertension
  DIS98MYE: Inherited disease susceptibility
  DISIVD4P: Essential hypertension, genetic

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
AGTR1	TT8DBY3	No Known	Unknown	[1]
ECE1	TTQ9RYT	No Known	Unknown	[2]
PTGIS	TTLXKZR	Limited	Unknown	[3]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AGTR1	OT2NRMJP	No Known	Unknown	[1]
ECE1	OTPFHC6F	No Known	Unknown	[2]
RGS5	OTUY0Q2I	No Known	Unknown	[4]
PTGIS	OTT3RW6N	Limited	Unknown	[3]

References

• [1] Use of Exome Sequencing for Infants in Intensive Care Units: Ascertainment of Severe Single-Gene Disorders and Effect on Medical Management. JAMA Pediatr. 2017 Dec 4;171(12):e173438. doi: 10.1001/jamapediatrics.2017.3438. Epub 2017 Dec 4.
• [2] Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation. Hum Mol Genet. 2003 Feb 15;12(4):423-33. doi: 10.1093/hmg/ddg040.
• [3] Splicing mutation of the prostacyclin synthase gene in a family associated with hypertension. Biochem Biophys Res Commun. 2002 Oct 11;297(5):1135-9. doi: 10.1016/s0006-291x(02)02341-0.
• [4] Multiple genes for essential-hypertension susceptibility on chromosome 1q. Am J Hum Genet. 2007 Feb;80(2):253-64. doi: 10.1086/510918. Epub 2006 Dec 20.