Details of Disease

General Information of Disease (ID: DISIYLND)

Disease Name Histiocytosis
Synonyms histiocytic and dendritic cell neoplasms; histiocytic syndrome; histiocytic infiltrate; hand Schuller Christian disease; chronic histiocytosis X
Definition A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes.
Disease Hierarchy
DIS57XO9: Lymphatic disease
DISIYLND: Histiocytosis
Disease Identifiers
MONDO ID
MONDO_0002637
MESH ID
D015614
UMLS CUI
C0019618
MedGen ID
6845
HPO ID
HP:0100727
SNOMED CT ID
60657004

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ARAF TT5TURO Strong Genetic Variation [1]
MAP2K2 TT8H9GB Strong Biomarker [2]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
KIF5B OTT34MT8 Strong Genetic Variation [3]
POU6F1 OTGSP4XJ Strong Biomarker [4]
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References

1 Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.Cancer Discov. 2016 Feb;6(2):154-65. doi: 10.1158/2159-8290.CD-15-0913. Epub 2015 Nov 13.
2 Efficacy of MEK inhibition in patients with histiocytic neoplasms.Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
3 Atypical juvenile histiocytosis with novel KIF5B-ALK gene fusion mimicking subglottic hemangioma.Int J Pediatr Otorhinolaryngol. 2019 Nov;126:109585. doi: 10.1016/j.ijporl.2019.07.010. Epub 2019 Jul 13.
4 The histopathology of Erdheim-Chester disease: a comprehensive review of a molecularly characterized cohort.Mod Pathol. 2018 Apr;31(4):581-597. doi: 10.1038/modpathol.2017.160. Epub 2017 Dec 1.