Details of Disease | DrugMAP

General Information of Disease (ID: DISJ6Y23)

Disease Name	Alzheimer disease 2
Synonyms	LOFAD; Alzheimer disease 2, late-onset; Alzheimer disease 2, late onset; Alzheimer disease associated with APOE E4; Alzheimer disease-2; Alzheimer disease type 2; AD2; Alzheimer's disease 2; Alzheimer's disease type 2; Alzheimer disease 2; late onset familial Alzheimer disease; Alzheimer disease associated with APOE4; late onset Alzheimer disease; late-onset familial alzheimer disease
Definition	An Alzheimer's disease that is characterized by an association of the apolipoprotein E E4 allele.
Disease Hierarchy	DISFWL8F: Hereditary dementia DISE75U4: Familial Alzheimer disease DISPN7D2: Inherited neurodegenerative disorder DISJ6Y23: Alzheimer disease 2
Disease Identifiers	MONDO ID MONDO_0007089 MESH ID C536595 UMLS CUI C1863051 OMIM ID 104310 MedGen ID 400197 SNOMED CT ID 230267005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PSEN1	TTZ3S8C	Limited	Genetic Variation	[1]
APOE	TTKS9CB	Definitive	Autosomal dominant	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
APOE	OTFOWL2H	Definitive	Autosomal dominant	[2]
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References

1	Alzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.Brain. 2010 Apr;133(Pt 4):1143-54. doi: 10.1093/brain/awq033.
2	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.