Details of Disease

General Information of Disease (ID: DISJUN66)

• Disease Name: Paraneoplastic syndrome
• Synonyms: paraneoplastic syndrome
• Definition: A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm.
• Disease Hierarchy:
  DIS6SVEE: Syndromic disease
  :
  DISJUN66: Paraneoplastic syndrome
• Disease Identifiers:
  MONDO ID: MONDO_0021073
  MESH ID: D010257
  UMLS CUI: C0030472
  MedGen ID: 45320
  SNOMED CT ID: 49783001

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
EPO	TTQG4NR	Limited	Biomarker	[1]
FGF23	TT2IZ4K	moderate	Biomarker	[2]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DPYSL5	OT6F9T6F	Limited	Biomarker	[3]
PHEX	OTG7N3J7	Limited	Altered Expression	[4]
PTHLH	OTI1JF13	moderate	Biomarker	[5]
CDR2	OTD3ZJST	Strong	Biomarker	[6]

References

• [1] Serum erythropoietin level in anemic cancer patients.Med Oncol. 2000 Feb;17(1):29-34. doi: 10.1007/BF02826213.
• [2] Tumor-induced osteomalacia - Current imaging modalities and a systematic approach for tumor localization.Clin Imaging. 2019 Jul-Aug;56:114-123. doi: 10.1016/j.clinimag.2019.04.007. Epub 2019 Apr 17.
• [3] CRMP5 antibodies found in a patient with limbic encephalitis and myasthenia gravis.J Neurol Neurosurg Psychiatry. 2009 Feb;80(2):241-2. doi: 10.1136/jnnp.2008.149336.
• [4] Cloning of human PEX cDNA. Expression, subcellular localization, and endopeptidase activity.J Biol Chem. 1998 May 29;273(22):13729-37. doi: 10.1074/jbc.273.22.13729.
• [5] Parathyroid hormone-related protein: an update.J Clin Endocrinol Metab. 2012 Sep;97(9):2947-56. doi: 10.1210/jc.2012-2142. Epub 2012 Jun 28.
• [6] Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response.Oncogene. 2009 Sep 17;28(37):3274-85. doi: 10.1038/onc.2009.186. Epub 2009 Jul 6.