Details of Disease

General Information of Disease (ID: DISK0X5T)

Disease Name	Yellow fever virus infection
Synonyms	Yellow fever virus caused disease or disorder; jungle yellow fever; urban yellow fever; YF; Yellow Jack; sylvatic yellow fever; Yellow fever virus disease or disorder; Yellow fever virus infectious disease; Yellow fever Virus infection; bronze John; Yellow fever, sylvan
Disease Class	1D47: Yellow fever
Definition	Yellow fever (YF), caused by YF virus, is a zoonotic disease characterized by fever and constitutional symptoms, with the potential to progress to severe and fatal viral hemorrhagic fever with shock and multi-organ system failure.
Disease Hierarchy	DISGFCIX: Vector-borne disease DIS7HTZ7: Arbovirus fever DISUDW4N: Flaviviridae infectious disease DISEM33Q: Infectious disease DISK0X5T: Yellow fever virus infection
ICD Code	ICD-11 ICD-11: 1D47 ICD-9 ICD-9: 780.6 Expand ICD-9 780.6
Disease Identifiers	MONDO ID MONDO_0020502 MESH ID D015004 UMLS CUI C0043395 MedGen ID 53112 Orphanet ID 99829 SNOMED CT ID 16541001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Arilvax	DM68POS	Approved	NA	[1]
Yellow fever vaccine	DMHCBAS	Approved	NA	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SP0218	DMX0KUG	Phase 2	Vaccine	[2]
XRX-001	DMBOJGS	Phase 1	NA	[3]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Flavimun	DMGH5NO	Discontinued in Preregistration	NA	[4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CYP20A1	OTIUZ6CF	Strong	Altered Expression	[5]
DDOST	OT39PDMS	Strong	Biomarker	[6]
EMC3	OTY2H39E	Strong	Biomarker	[7]
GYPC	OTOEDR7O	Strong	Biomarker	[8]
RPL19	OT33LM66	Strong	Biomarker	[6]
TRIM56	OTFGU8E3	Strong	Biomarker	[9]
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⏷ Show the Full List of 6 DOT(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of Sanofi
3	ClinicalTrials.gov (NCT00995865) Trial of Yellow Fever Inactivated Vaccine. U.S. National Institutes of Health.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024484)
5	Bacteria-mediated modification of insecticide toxicity in the yellow fever mosquito, Aedes aegypti.Pestic Biochem Physiol. 2019 Nov;161:77-85. doi: 10.1016/j.pestbp.2019.07.016. Epub 2019 Aug 2.
6	Uncovering Flavivirus Host Dependency Factors through a Genome-Wide Gain-of-Function Screen.Viruses. 2019 Jan 15;11(1):68. doi: 10.3390/v11010068.
7	Dual roles for the ER membrane protein complex in flavivirus infection: viral entry and protein biogenesis.Sci Rep. 2019 Jul 4;9(1):9711. doi: 10.1038/s41598-019-45910-9.
8	A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins.Virology. 2006 Feb 20;345(2):299-304. doi: 10.1016/j.virol.2005.12.001. Epub 2006 Jan 18.
9	The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis.J Virol. 2016 Apr 14;90(9):4369-4382. doi: 10.1128/JVI.03172-15. Print 2016 May.