Details of Disease | DrugMAP

General Information of Disease (ID: DISKFZG7)

Disease Name	Orofacial cleft 11
Synonyms	congenital Healed cleft lip; cleft Lip, congenital Healed; OFC11; cleft lip with or without cleft palate, nonsyndromic, 11; orofacial cleft caused by mutation in BMP4; orofacial cleft 11; orofacial cleft type 11; BMP4 orofacial cleft
Definition	Any orofacial cleft in which the cause of the disease is a mutation in the BMP4 gene.
Disease Hierarchy	DIST1HG6: Orofacial cleft DIS14IG3: Cleft lip/palate DISKFZG7: Orofacial cleft 11
Disease Identifiers	MONDO ID MONDO_0010906 MESH ID C567410 UMLS CUI C2677434 OMIM ID 600625 MedGen ID 436944

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BMP4	TTD3BSX	Limited	Autosomal dominant	[1]
BMP4	TTD3BSX	Limited	Genetic Variation	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BMP4	OTPZMDFH	Limited	Autosomal dominant	[1]
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References

1	Mutations in BMP4 are associated with subepithelial, microform, and overt cleft lip. Am J Hum Genet. 2009 Mar;84(3):406-11. doi: 10.1016/j.ajhg.2009.02.002. Epub 2009 Feb 26.