Details of Disease

General Information of Disease (ID: DISKJHLL)

Disease Name	Hand, foot and mouth disease
Synonyms	HFMD; hand, foot, and mouth disease; hand foot and mouth disease; vesicular stomatitis and exanthem
Disease Class	1F05: Picornavirus infection
Definition	A clinical syndrome that is usually caused by enterovirus infection, and that is characterized by fever, anorexia, and painful sores in the mouth, distal extremities, and/or other sites, including the buttocks.
Disease Hierarchy	DISY1VPA: Coxsackie virus infection DISFDJN8: Skin disorder caused by infection DISKJHLL: Hand, foot and mouth disease
ICD Code	ICD-11 ICD-11: 1F05.0 ICD-10 ICD-10: B08.4 Expand ICD-11 '1F05.0 Expand ICD-10 'B08.4
Disease Identifiers	MONDO ID MONDO_0005779 MESH ID D006232 UMLS CUI C0018572 MedGen ID 42330 SNOMED CT ID 266108008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
INV-21	DMIQ0C5	Phase 1	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
IFNAR2	TTMQB37	Strong	Biomarker	[2]
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This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AQP4	OTA9MYD5	Limited	Biomarker	[3]
ATG4B	OTQ4RNRM	Limited	Altered Expression	[4]
SCARB2	OTN929M8	Limited	Biomarker	[5]
ATP1A3	OTM8EG6H	Strong	Biomarker	[6]
CA10	OTC3N1F6	Strong	Biomarker	[7]
CERS1	OT6EYRM3	Strong	Biomarker	[8]
OAS1	OT8ZLOCY	Strong	Genetic Variation	[9]
SCARA3	OT46I38Y	Strong	Biomarker	[10]
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⏷ Show the Full List of 8 DOT(s)

References

1	ClinicalTrials.gov (NCT01376479) Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71. U.S. National Institutes of Health.
2	A Single Mutation in the VP1 of Enterovirus 71 Is Responsible for Increased Virulence and Neurotropism in Adult Interferon-Deficient Mice.J Virol. 2016 Sep 12;90(19):8592-604. doi: 10.1128/JVI.01370-16. Print 2016 Oct 1.
3	Distinct expression and clinical value of aquaporin 4 in children with hand, foot and mouth disease caused by enterovirus 71.J Med Virol. 2022 Feb;94(2):587-593. doi: 10.1002/jmv.25475. Epub 2019 Apr 23.
4	Activity-Based Protein Profiling Identifies ATG4B as a Key Host Factor for Enterovirus 71 Proliferation.J Virol. 2019 Nov 26;93(24):e01092-19. doi: 10.1128/JVI.01092-19. Print 2019 Dec 15.
5	Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.Nat Microbiol. 2019 Mar;4(3):414-419. doi: 10.1038/s41564-018-0319-z. Epub 2018 Dec 10.
6	Impact of Drinking Water Quality on the Development of Enteroviral Diseases in Korea.Int J Environ Res Public Health. 2018 Nov 14;15(11):2551. doi: 10.3390/ijerph15112551.
7	Construction and characterization of an infectious cDNA clone of coxsackievirus A 10.Virol J. 2019 Aug 6;16(1):98. doi: 10.1186/s12985-019-1201-1.
8	Short-term exposure to sulfur dioxide and the risk of childhood hand, foot, and mouth disease during different seasons in Hefei, China.Sci Total Environ. 2019 Mar 25;658:116-121. doi: 10.1016/j.scitotenv.2018.11.481. Epub 2018 Dec 2.
9	A functional polymorphism in IFNAR1 gene is associated with susceptibility and severity of HFMD with EV71 infection.Sci Rep. 2015 Dec 18;5:18541. doi: 10.1038/srep18541.
10	Scavenger receptor class a, member 3 is associated with severity of hand, foot, and mouth disease in a case-control study.Medicine (Baltimore). 2019 Oct;98(40):e17471. doi: 10.1097/MD.0000000000017471.