Details of Disease

General Information of Disease (ID: DISKRB4V)

Disease Name Diabetic cataract
Synonyms cataract - diabetic
Disease Class 9B10: Cataract
Disease Hierarchy
DISUD7SL: Cataract
DISKRB4V: Diabetic cataract
ICD Code
ICD-11
ICD-11: 9B10.21
ICD-10
ICD-10: H28.0
Expand ICD-11
'9B10.21
Expand ICD-10
'H28.0
Disease Identifiers
MONDO ID
MONDO_0001687
UMLS CUI
C0011876
MedGen ID
507634
SNOMED CT ID
43959009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
RTU-007 DMHLYAD Approved NA [1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
SSR-125047 DMSUFW6 Phase 1 Small molecular drug [2]
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This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
E-0722 DM2PVMZ Terminated Small molecular drug [3]
Sorbinil DM31VE4 Terminated Small molecular drug [4]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
VLD-01 DM6GGHO Investigative NA [5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AKR1B1 TTFBNVI Strong Altered Expression [6]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CAPN3 OTCHG3YK Strong Biomarker [7]
CAPN5 OTQ8QM7K Strong Altered Expression [7]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7404).
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800004685)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7415).
5 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
6 Protective effect of glycine in streptozotocin-induced diabetic cataract through aldose reductase inhibitory activity.Biomed Pharmacother. 2019 Jun;114:108794. doi: 10.1016/j.biopha.2019.108794. Epub 2019 Apr 1.
7 Calpains and their multiple roles in diabetes mellitus.Ann N Y Acad Sci. 2006 Nov;1084:452-80. doi: 10.1196/annals.1372.011.