Details of Disease

General Information of Disease (ID: DISM4F09)

• Disease Name: Hypertensive emergency
• Synonyms: MHT; hypertensive emergency; malignant phase hypertension; accelerated-malignant hypertension
• Disease Class: BA03: Hypertensive crisis
• Definition: Severe hypertension that is characterized by rapid onset of extremely high blood pressure.
• Disease Hierarchy:
  DISR4QMU: Increase blood pressure
  DISM4F09: Hypertensive emergency
• ICD Code: ICD-11: ICD-11: BA03
• Disease Identifiers:
  MONDO ID: MONDO_0006846
  MESH ID: D006974
  UMLS CUI: C0020540
  MedGen ID: 9374
  SNOMED CT ID: 70272006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Diazoxide	DML1538	Approved	Small molecular drug	[1]
Phentolamine	DMXYJOB	Approved	Small molecular drug	[2]
Trimethaphan	DMHF4IQ	Approved	Small molecular drug	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CYP17A1	TTRA5BZ	Limited	Biomarker	[4]
TXNRD3	TTDYFVB	Limited	Biomarker	[5]
AGT	TT5C0UB	Strong	Biomarker	[6]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MAT2B	DEKF1OH	Limited	Biomarker	[5]

References

• [1] Diazoxide FDA Label
• [2] Phentolamine FDA Label
• [3] Drug information of Trimethaphan, 2008. eduDrugs.
• [4] [Malignant arterial hypertension disclosing late congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency].Arch Mal Coeur Vaiss. 1988 Jun;81 Spec No:93-5.
• [5] Enhanced urinary angiotensinogen excretion in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension.Am J Med Sci. 2010 Nov;340(5):389-94. doi: 10.1097/MAJ.0b013e3181eabd28.
• [6] Plasma heme-induced renal toxicity is related to a capillary rarefaction.Sci Rep. 2017 Jan 10;7:40156. doi: 10.1038/srep40156.