Details of Disease | DrugMAP

General Information of Disease (ID: DISMXUGF)

Disease Name	Migraine, familial hemiplegic, 3
Synonyms	FHM3; familial or sporadic hemiplegic migraine caused by mutation in SCN1A; SCN1A familial or sporadic hemiplegic migraine; migraine, familial hemiplegic, type 3; migraine, familial hemiplegic, 3
Definition	Any familial or sporadic hemiplegic migraine in which the cause of the disease is a mutation in the SCN1A gene.
Disease Hierarchy	DISYVMKL: Familial hemiplegic migraine DISMXUGF: Migraine, familial hemiplegic, 3
Disease Identifiers	MONDO ID MONDO_0012320 MESH ID C566500 UMLS CUI C1864987 OMIM ID 609634 MedGen ID 400655

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SCN1A	TTANOZH	moderate	Biomarker	[1]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SCN1A	DTN0M1I	Strong	Autosomal dominant	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SCN1A	OTJ9ZTYI	Strong	Autosomal dominant	[2]
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References

1	Two novel families with hemiplegic migraine caused by recurrent SCN1A mutation p.F1499L.Cephalalgia. 2018 Jul;38(8):1503-1508. doi: 10.1177/0333102417742365. Epub 2017 Nov 16.
2	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.