Details of Disease

Disease Name

Renal osteodystrophy

Osteodystrophies, renal; rickets, renal; osteodystrophy, renal; renal Osteodystrophies; renal rickets

Definition

Abnormalities of bone mineral metabolism associated with chronic kidney disease.

Disease Hierarchy

DISDPT16: Secondary hyperparathyroidism of renal origin

DISH89YF: Rickets

DISN2OO5: Renal osteodystrophy

Disease Identifiers

MONDO ID

MONDO_0006946

MESH ID

D012080

UMLS CUI

C0035086

MedGen ID

20524

SNOMED CT ID

16726004

General Information of Disease (ID: DISN2OO5)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calcidiol	DMN4CV5	Approved	Small molecular drug	[1]
Calcitriol	DM8ZVJ7	Approved	Small molecular drug	[2]
Alfacalcidol	DM1237M	Phase 4	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GJD2	TTOZAFI	Definitive	Biomarker	[4]
GUCY2D	TTWNFC2	Definitive	Genetic Variation	[5]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ERAL1	OTSH78HD	Definitive	Biomarker	[6]
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References

1	Patterns of renal osteodystrophy 1?year after kidney transplantation. Nephrol Dial Transplant. 2021 Nov 9;36(11):2130-2139.
2	Calcitriol FDA Label
3	Cross-linked C-terminal telopeptide of type I collagen in serum before and after treatment with alfacalcidol and calcium carbonate in early and moderate chronic renal failure. Nephron. 2002 Oct;92(2):304-8.
4	Connexin 36 expression is required for electrical coupling between mouse rods and cones.Vis Neurosci. 2017 Jan;34:E006. doi: 10.1017/S0952523817000037.
5	Whole exome sequencing reveals GUCY2D as a major gene associated with cone and cone-rod dystrophy in Israel.Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):420-30. doi: 10.1167/iovs.14-15647.
6	Bone biopsy practice patterns across Europe: the European renal osteodystrophy initiative-a position paper.Nephrol Dial Transplant. 2017 Oct 1;32(10):1608-1613. doi: 10.1093/ndt/gfw468.