Details of Disease | DrugMAP

General Information of Disease (ID: DISOAROS)

Disease Name	Dysplasia of cervix
Definition	Abnormal development of immature squamous epithelial cells of the uterine cervix, a term used to describe premalignant cytological changes in the cervical epithelium. These atypical cells do not penetrate the epithelial basement membrane.
Disease Hierarchy	DIS7W23Z: Reproductive system disorder DISOAROS: Dysplasia of cervix
Disease Identifiers	MONDO ID MONDO_0006736 MESH ID D002578 UMLS CUI C0007868 MedGen ID 2971 HPO ID HP:0032131 SNOMED CT ID 73391008

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
REG3A	TTL4H8N	Strong	Genetic Variation	[1]
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This Disease Is Related to 13 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
EPB41L3	OTS6CHG2	Strong	Biomarker	[2]
LPIN1	OTQ75KF2	Strong	Altered Expression	[3]
MCM5	OTAHLB62	Strong	Biomarker	[4]
METTL9	OT3YR9B2	Strong	Altered Expression	[3]
MRPS30	OTDXIAGG	Strong	Genetic Variation	[1]
MTPAP	OT6HQ02S	Strong	Genetic Variation	[1]
MTREX	OTSQY30V	Strong	Genetic Variation	[5]
PAPOLA	OTPHD65D	Strong	Genetic Variation	[1]
PDAP1	OTJSWMOD	Strong	Genetic Variation	[1]
PLAA	OTZ7NJGA	Strong	Biomarker	[5]
POU4F3	OTILD0XS	Strong	Biomarker	[6]
RP9	OTGQY66H	Strong	Altered Expression	[3]
SEC62	OTCWEL5F	Strong	Altered Expression	[7]
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⏷ Show the Full List of 13 DOT(s)

References

1	Adherence to gynecological screening impacted by experienced orthodontic treatment in childhood.Arch Gynecol Obstet. 2019 Jan;299(1):167-171. doi: 10.1007/s00404-018-4950-y. Epub 2018 Oct 30.
2	Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer.Int J Cancer. 2017 Aug 15;141(4):701-710. doi: 10.1002/ijc.30781. Epub 2017 May 26.
3	PCR-based high-risk HPV test in cervical cancer screening gives objective risk assessment of women with cytomorphologically normal cervical smears.Int J Cancer. 1996 Dec 11;68(6):766-9. doi: 10.1002/(SICI)1097-0215(19961211)68:6<766::AID-IJC13>3.0.CO;2-Z.
4	Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix.Mod Pathol. 2005 Jun;18(6):844-9. doi: 10.1038/modpathol.3800361.
5	HLA DOA1 and DOB1 loci in Honduran women with cervical dysplasia and invasive cervical carcinoma and their relationship to human papillomavirus infection.Hum Biol. 1999 Jun;71(3):367-79.
6	Performance of a new HPV and biomarker assay in the management of hrHPV positive women: Subanalysis of the ongoing multicenter TRACE clinical trial (n??,000) to evaluate POU4F3 methylation as a potential biomarker of cervical precancer and cancer.Int J Cancer. 2017 Mar 1;140(5):1119-1133. doi: 10.1002/ijc.30534.
7	Sec62/Ki67 dual staining in cervical cytology specimens: a new marker for high-grade dysplasia.Arch Gynecol Obstet. 2019 Feb;299(2):481-488. doi: 10.1007/s00404-018-4981-4. Epub 2018 Nov 29.