General Information of Disease (ID: DISOFUFW)

Disease Name Ischemic optic neuropathy
Synonyms aion; optic disc infarction leading to vision loss; optic disk infarction leading to vision loss; ischaemic optic neuropathy; ischemic optic neuropathy
Disease Class 9C40: Optic nerve disorder
Definition
Anterior ischemic optic neuropathy (AION) is an eye disease characterized by infarction of the optic disk leading to vision loss. It can be nonarteritic (nonarteritic anterior ischemic optic neuropathy or NAION) or arteritic, the latter being associated with giant cell arteritis (GCA; often termed temporal arteritis). Vision loss with both varieties is typically rapid (over minutes, hours, or days) and painless. Symptoms such as a general feeling of being unwell (malaise), muscle aches and pains, headaches over the temple, pain when combing hair, pain in the jaw after chewing, and tenderness over the temporal artery (one of the major arteries of the head) may be present with giant cell arteritis. At exam, visual acuity is reduced and the optic disk is swollen. In both subtypes, visual field examination is often reduced in the inferior and central visual fields. The visual loss is usually permanent, with some recovery possibly occurring within the first weeks or months. The arteritic variety is treated with corticosteroids. Treatment of the nonarteritic variety withaspirinor corticosteroids has not been helpful.
Disease Hierarchy
DISSOQM8: Optic nerve disorder
DISOFUFW: Ischemic optic neuropathy
ICD Code
ICD-11
ICD-11: 9C40.4
Expand ICD-11
'9C40.4
Disease Identifiers
MONDO ID
MONDO_0006649
MESH ID
D018917
UMLS CUI
C0751711
MedGen ID
199716
SNOMED CT ID
404659001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
QPI-1007 DMUWXEB Phase 3 siRNA drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)