Details of Disease

General Information of Disease (ID: DISOV578)

Disease Name	Perianal crohn disease
Synonyms	perianal Crohn's disease
Disease Class	DD70: Crohn disease
Definition	An Crohn disease involving a pathogenic inflammatory response in the anal canal.
Disease Hierarchy	DISKU8JE: Large intestine disorder DIS2C5Q8: Crohn disease DISXQCG5: Gastroenteritis DISOV578: Perianal crohn disease
ICD Code	ICD-11 ICD-11: DD70.4 Expand ICD-11 'DD70.4
Disease Identifiers	MONDO ID MONDO_0005537 UMLS CUI C0341395 MedGen ID 574362 SNOMED CT ID 235796008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Metronidazole	DMTIVEN	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CRTC3	OTVIGVUW	Strong	Biomarker	[2]
KIF3B	OT0HJREB	Strong	Biomarker	[2]
NRIP1	OTIZOJQV	Strong	Biomarker	[2]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Perianal Crohn's Disease is Associated with Distal Colonic Disease, Stricturing Disease Behavior, IBD-Associated Serologies and Genetic Variation in the JAK-STAT Pathway.Inflamm Bowel Dis. 2016 Apr;22(4):862-9. doi: 10.1097/MIB.0000000000000705.