Details of Disease | DrugMAP

General Information of Disease (ID: DISOWS20)

Disease Name	Meconium ileus
Synonyms	meconium ileus
Definition	Small intestinal obstruction that results from the impaction of thick meconium in the distal small intestine.
Disease Hierarchy	DISH7JW9: Ileus DISOWS20: Meconium ileus
Disease Identifiers	MONDO ID MONDO_0054868 UMLS CUI C2939175 OMIM ID 614665 MedGen ID 473705 HPO ID HP:0004401 SNOMED CT ID 206523001

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CFTR	TTRLZHP	moderate	Genetic Variation	[1]
SLC26A9	TTKRVU0	moderate	Biomarker	[2]
CLCA1	TT3AF4R	Strong	Genetic Variation	[3]
PRSS1	TT2WR1T	Strong	Genetic Variation	[2]
SLC6A14	TTB6H2S	Strong	Biomarker	[2]
SLC9A3	TTFZVPO	Strong	Genetic Variation	[4]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MSRA	DEU2ZBY	Strong	Biomarker	[5]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GUCA2A	OTUSF75G	Limited	Genetic Variation	[6]
FEV	OTYEC4IR	Strong	Genetic Variation	[7]
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References

1	Cystic Fibrosis Liver Disease: Outcomes and Risk Factors in a Large Cohort of French Patients.Hepatology. 2019 Apr;69(4):1648-1656. doi: 10.1002/hep.30148. Epub 2018 Dec 28.
2	Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci.PLoS Genet. 2019 Feb 26;15(2):e1008007. doi: 10.1371/journal.pgen.1008007. eCollection 2019 Feb.
3	Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):347-9. doi: 10.1097/MPG.0b013e3181afce6c.
4	Unraveling the complex genetic model for cystic fibrosis: pleiotropic effects of modifier genes on early cystic fibrosis-related morbidities.Hum Genet. 2014 Feb;133(2):151-61. doi: 10.1007/s00439-013-1363-7. Epub 2013 Sep 22.
5	Variation in MSRA modifies risk of neonatal intestinal obstruction in cystic fibrosis.PLoS Genet. 2012;8(3):e1002580. doi: 10.1371/journal.pgen.1002580. Epub 2012 Mar 15.
6	Computational analyses and prediction of guanylin deleterious SNPs.Peptides. 2015 Jul;69:92-102. doi: 10.1016/j.peptides.2015.04.013. Epub 2015 Apr 18.
7	Body composition and lung function in children with cystic fibrosis and meconium ileus.Eur J Pediatr. 2017 Jun;176(6):737-743. doi: 10.1007/s00431-017-2906-z. Epub 2017 Apr 13.