Details of Disease | DrugMAP

General Information of Disease (ID: DISOX567)

Disease Name	Spermatogenic failure 12
Synonyms	SPGF12; spermatogenic failure type 12; azoospermia caused by mutation in NANOS1; NANOS1 azoospermia; spermatogenic failure 12
Definition	Any azoospermia in which the cause of the disease is a mutation in the NANOS1 gene.
Disease Hierarchy	DISPY5W6: Male infertility with teratozoospermia due to single gene mutation DIS3D1AI: Spermatogenic failure DISOX567: Spermatogenic failure 12
Disease Identifiers	MONDO ID MONDO_0014172 UMLS CUI C3809427 OMIM ID 615413 MedGen ID 815757

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NANOS1	OT3UNZZY	Limited	Unknown	[1]
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References

1	Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia. J Med Genet. 2013 Mar;50(3):187-93. doi: 10.1136/jmedgenet-2012-101230. Epub 2013 Jan 12.