Details of Disease

General Information of Disease (ID: DISP3NHR)

Disease Name Typhoid fever
Synonyms typhoid fever; typhoid; typhoidal salmonellosis
Disease Class 1A07: Typhoid fever
Definition A bacterial infectious disorder contracted by consumption of food or drink contaminated with Salmonella typhi. This disorder is common in developing countries and can be treated with antibiotics.
Disease Hierarchy
DISTJ434: Salmonella infection
DISP3NHR: Typhoid fever
ICD Code
ICD-11
ICD-11: 1A07
ICD-10
ICD-10: A01.0
Expand ICD-11
'1A07
Expand ICD-10
'A01.0
Disease Identifiers
MONDO ID
MONDO_0005619
MESH ID
D014435
UMLS CUI
C0041466
MedGen ID
11973
Orphanet ID
99745
SNOMED CT ID
4834000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Typhella typhoid vaccine DMT9K37 Discontinued in Phase 2 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
HLA-DRB1 TTUXSTW Strong Genetic Variation [3]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CDK2AP1 OTNFOHDJ Strong Genetic Variation [4]
GYPB OTESHUIX Strong Biomarker [5]
GYPE OTBHAG6A Strong Biomarker [5]
PACRG OT1NYNNW Strong Genetic Variation [6]
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References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011695)
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3 In Silico Characterization of B Cell and T Cell Epitopes for Subunit Vaccine Design of Salmonella typhi PgtE: A Molecular Dynamics Simulation Approach.J Comput Biol. 2019 Feb;26(2):105-116. doi: 10.1089/cmb.2018.0010. Epub 2018 Dec 14.
4 Epidemiology and Genomics of Invasive Nontyphoidal Salmonella Infections in Kenya.Clin Infect Dis. 2015 Nov 1;61 Suppl 4(Suppl 4):S317-24. doi: 10.1093/cid/civ711.
5 ABO, Rh, MNSs, sex and typhoid fever.Hum Hered. 1993 Sep-Oct;43(5):301-10. doi: 10.1159/000154148.
6 PARK2/PACRG polymorphisms and susceptibility to typhoid and paratyphoid fever.Clin Exp Immunol. 2006 Jun;144(3):425-31. doi: 10.1111/j.1365-2249.2006.03087.x.