Details of Disease

General Information of Disease (ID: DISPRY75)

Disease Name Fetal trimethadione syndrome
Disease Class LD2F: Multiple structural anomalies syndrome
Definition
Fetal trimethadione syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to trimethadione and that is characterized by pre- and post-natal growth retardation, intellectual deficit, developmental and speech delay, craniofacial anomalies (with some similarities to those seen in fetal valproate syndrome), and less commonly, cleft palate, malformations of the heart, urogenital system and limbs. Trimethadione is an antiepileptic drug that has been removed from the market in Europe and is no longer used much in other countries due to teratogenicity and potential side effects.
Disease Hierarchy
DISBLXJ0: Toxic or drug-related embryofetopathy
DISPRY75: Fetal trimethadione syndrome
ICD Code
ICD-11
ICD-11: LD2F.0Y
Disease Identifiers
MONDO ID
MONDO_0016009
MESH ID
C537798
UMLS CUI
C0265373
MedGen ID
120538
Orphanet ID
1913
SNOMED CT ID
66351003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Paramethadione DMR5ZUP Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7261).