Details of Disease

General Information of Disease (ID: DISQ2U9O)

Disease Name Inappropriate ADH syndrome
Synonyms
ectopic ADH secretion; syndrome of inappropriate secretion of antidiuretic hormone; syndrome of inappropriate antidiuretic hormone; syndrome of inappropriate antidiuretic hormone secretion; inappropriate Arginine vasopressin secretion; ectopic antidiuretic hormone secretion; syndrome of inappropriate vasopressin secretion; inappropriate antidiuretic hormone secretion syndrome; SIADH; inappropriate ADH secretion; syndrome of inappropriate secretion of ADH
Definition A syndrome characterized by abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.
Disease Hierarchy
DISD21YZ: Ectopic hormone secretion syndrome associated with neoplasia
DIS7XB48: Pituitary gland disorder
DISQ2U9O: Inappropriate ADH syndrome
Disease Identifiers
MONDO ID
MONDO_0006802
MESH ID
D007177
UMLS CUI
C0021141
MedGen ID
5772
HPO ID
HP:0031218
Orphanet ID
83449
SNOMED CT ID
55004003

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
HMBS TTT0HW3 Limited Genetic Variation [1]
AVPR2 TTK8R02 Strong Biomarker [2]
PPOX TTNFMS9 Strong Genetic Variation [3]
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References

1 Novel A219P mutation of hydroxymethylbilane synthase identified in a Chinese woman with acute intermittent porphyria and syndrome of inappropriate antidiuretic hormone.Ann Hum Genet. 2015 Jul;79(4):310-2. doi: 10.1111/ahg.12107. Epub 2015 Mar 18.
2 Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree. J Am Soc Nephrol. 2007 Feb;18(2):606-12. doi: 10.1681/ASN.2006090987. Epub 2007 Jan 17.
3 Novel mutation of PPOX gene in a patient with abdominal pain and syndrome of inappropriate antidiuresis.Endocrine. 2018 Sep;61(3):403-406. doi: 10.1007/s12020-018-1569-5. Epub 2018 Mar 7.