Details of Disease | DrugMAP

General Information of Disease (ID: DISQEBTU)

Disease Name	Viral hemorrhagic fever
Synonyms	hemorrhagic fevers; hemorrhagic fever; haemorrhagic fever; VHF; viral haemorrhagic fever; haemorrhagic fevers, viral; VHFs
Definition	A viral infectious disease caused by RNA viruses in the Arenaviridae, Bunyaviridae, Filoviridae, or Flaviviridae family, and characterized by a severe multisystem syndrome, with damage to the vascular system and hemorrhaging.
Disease Hierarchy	DISH18LB: Hemorrhagic fever DISFYSIV: Virus infection DISQEBTU: Viral hemorrhagic fever
Disease Identifiers	MONDO ID MONDO_0018087 MESH ID D006482 UMLS CUI C0019104 MedGen ID 9213 Orphanet ID 341 SNOMED CT ID 240523007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ATRAID	TTFLIKM	Strong	Genetic Variation	[1]
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This Disease Is Related to 9 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TRIM6	OTBSMX0B	Limited	Biomarker	[2]
ARSF	OTC0L12N	Strong	Biomarker	[3]
EEF1E1	OTRA6XOB	Strong	Genetic Variation	[1]
LAMTOR1	OTIBJBW9	Strong	Genetic Variation	[1]
MAFK	OTZJUE4P	Strong	Genetic Variation	[1]
PSMD4	OTH1VZTM	Strong	Biomarker	[3]
TMBIM4	OT8712PP	Strong	Biomarker	[4]
TPPP2	OTI3WA6X	Strong	Genetic Variation	[1]
TRIM2	OT0V1YVC	Strong	Biomarker	[5]
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⏷ Show the Full List of 9 DOT(s)

References

1	Cytokine patterns in a comparative model of arenavirus haemorrhagic fever in guinea pigs.J Gen Virol. 2008 Oct;89(Pt 10):2569-2579. doi: 10.1099/vir.0.2008/002048-0.
2	The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication.J Virol. 2017 Aug 24;91(18):e00833-17. doi: 10.1128/JVI.00833-17. Print 2017 Sep 15.
3	In silico structural and functional prediction of African swine fever virus protein-B263R reveals features of a TATA-binding protein.PeerJ. 2018 Feb 22;6:e4396. doi: 10.7717/peerj.4396. eCollection 2018.
4	A Highly Conserved Leucine in Mammarenavirus Matrix Z Protein Is Required for Z Interaction with the Virus L Polymerase and Z Stability in Cells Harboring an Active Viral Ribonucleoprotein.J Virol. 2018 May 14;92(11):e02256-17. doi: 10.1128/JVI.02256-17. Print 2018 Jun 1.
5	TRIM2, a novel member of the antiviral family, limits New World arenavirus entry.PLoS Biol. 2019 Feb 6;17(2):e3000137. doi: 10.1371/journal.pbio.3000137. eCollection 2019 Feb.