Details of Disease | DrugMAP

General Information of Disease (ID: DISQL23S)

Disease Name	Obsolete sodium channelopathy-related small fiber neuropathy
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DISQL23S: Obsolete sodium channelopathy-related small fiber neuropathy

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SCN10A	TT90XZ8	Supportive	Autosomal dominant	[1]
SCN11A	TTN9VTF	Supportive	Autosomal dominant	[2]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SCN9A	DTQC85B	Supportive	Autosomal dominant	[3]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SCN10A	OTPCGJAC	Supportive	Autosomal dominant	[1]
SCN11A	OTY0HJJZ	Supportive	Autosomal dominant	[2]
SCN9A	OTGSKLL8	Supportive	Autosomal dominant	[3]
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References

1	Gain-of-function Nav1.8 mutations in painful neuropathy. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19444-9. doi: 10.1073/pnas.1216080109. Epub 2012 Oct 31.
2	Gain-of-function mutations in sodium channel Na(v)1.9 in painful neuropathy. Brain. 2014 Jun;137(Pt 6):1627-42. doi: 10.1093/brain/awu079. Epub 2014 Apr 27.
3	Gain of function Na1.7 mutations in idiopathic small fiber neuropathy. Ann Neurol. 2012 Jan;71(1):26-39. doi: 10.1002/ana.22485. Epub 2011 Jun 22.