Details of Disease

General Information of Disease (ID: DISQXGDY)

• Disease Name: Autosomal recessive nonsyndromic hearing loss 16
• Synonyms: deafness, autosomal recessive 16; autosomal recessive deafness 16; STRC autosomal recessive nonsyndromic deafness; deafness, autosomal recessive type 16; DFNB16; autosomal recessive nonsyndromic deafness type 16; autosomal recessive nonsyndromic deafness caused by mutation in STRC; autosomal recessive nonsyndromic deafness 16; autosomal recessive nonsyndromic hearing loss 16
• Definition: Any autosomal recessive nonsyndromic deafness in which the cause of the disease is a mutation in the STRC gene.
• Disease Hierarchy:
  DIS8G9R9: Hearing loss, autosomal recessive
  DISQXGDY: Autosomal recessive nonsyndromic hearing loss 16
• Disease Identifiers:
  MONDO ID: MONDO_0011364
  MESH ID: C566339
  UMLS CUI: C1863561
  OMIM ID: 603720
  MedGen ID: 350211

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
STRC	OT3JQYVJ	Strong	Autosomal recessive	[1]
TMPRSS3	OT0GTO1Z	Strong	Biomarker	[2]

References

• [1] Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus. Nat Genet. 2001 Nov;29(3):345-9. doi: 10.1038/ng726.
• [2] Hereditary deafness and phenotyping in humans.Br Med Bull. 2002;63:73-94. doi: 10.1093/bmb/63.1.73.