Details of Disease

General Information of Disease (ID: DISRYD6K)

Disease Name	Myocardial disease
Synonyms	disorder of heart muscle; myocardial disorder; myocardium disease or disorder; myocardial disease; disease of myocardium; disorder of myocardium; disease or disorder of myocardium; myocardium disease
Disease Class	BC43: Cardiomyopathy
Definition	A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy.
Disease Hierarchy	DISWD40R: Disease DISVO1I5: Cardiac disease DISRYD6K: Myocardial disease
ICD Code	ICD-11 ICD-11: BC43.20 ICD-10 ICD-10: I42.3, I42.4 Expand ICD-11 'BC43.20 Expand ICD-10 'I42.3; 'I42.4
Disease Identifiers	MONDO ID MONDO_0024643 UMLS CUI C3241958 MedGen ID 469033

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
99mTc-teboroxime	DM35GJQ	Approved	NA	[1]
BY-963	DMW0UL9	Approved	NA	[2]
Iodofiltic acid I-123	DM6ABBY	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Flurpiridaz F 18	DMKL5AT	Phase 3	Small molecular drug	[3]
OTI-020	DMQZDL9	Phase 3	NA	[4]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SR8278	DMSK5N3	Preclinical	Small molecular drug	[5]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARSH	OTG0X9UQ	Strong	Biomarker	[6]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006429)
3	ClinicalTrials.gov (NCT01347710) A Phase 3 Multi-center Study to Assess PET Imaging of Flurpiridaz F 18 Injection in Patients With CAD.. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT01233960) Evaluation of PROCHYMAL for Treatment-refractory Moderate-to-severe Crohn's Disease. U.S. National Institutes of Health.
5	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
6	Congenital heart malformations associated with disproportionate ventricular septal thickening.Circulation. 1975 Nov;52(5):926-32. doi: 10.1161/01.cir.52.5.926.