Details of Disease | DrugMAP

General Information of Disease (ID: DISS963W)

Disease Name	Obsolete severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DISS963W: Obsolete severe neonatal lactic acidosis due to NFS1-ISD11 complex deficiency

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
LYRM4	OTK6JCKL	Supportive	Autosomal recessive	[1]
NFS1	OT0HUS40	Supportive	Autosomal recessive	[2]
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References

1	Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum Mol Genet. 2013 Nov 15;22(22):4460-73. doi: 10.1093/hmg/ddt295. Epub 2013 Jun 28.
2	Exome sequencing identifies NFS1 deficiency in a novel Fe-S cluster disease, infantile mitochondrial complex II/III deficiency. Mol Genet Genomic Med. 2014 Jan;2(1):73-80. doi: 10.1002/mgg3.46. Epub 2013 Nov 18.