Details of Disease | DrugMAP

General Information of Disease (ID: DISSJLBN)

Disease Name	Pneumoconiosis
Synonyms	coal worker's pneumoconiosis; Black lung disease
Definition	An occupational lung disorder caused by inhalation of dust particles. It is characterized by bilateral interstitial lung infiltrates. Representative examples include asbestosis, silicosis, anthracosis, and talc pneumoconiosis.
Disease Hierarchy	DISWSHC6: Interstitial lung disease DISSJLBN: Pneumoconiosis
Disease Identifiers	MONDO ID MONDO_0015926 MESH ID D011009 UMLS CUI C0032273 MedGen ID 19360 Orphanet ID 182098 SNOMED CT ID 40122008

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CPM	TTVOH2M	Limited	Genetic Variation	[1]
ATR	TT8ZYBQ	Strong	Biomarker	[2]
CA1	TTHQPL7	Strong	Biomarker	[2]
CA3	TTXUK5D	Strong	Biomarker	[2]
IL4	TTLGTKB	Strong	Biomarker	[3]
MDM4	TT9OUDQ	Strong	Biomarker	[2]
PTPRZ1	TT4SEA8	Strong	Biomarker	[2]
TICAM1	TT2GQT6	Strong	Biomarker	[2]
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⏷ Show the Full List of 8 DTT(s)

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACAN	OTUOCW8K	Strong	Biomarker	[2]
CDH23	OTOJGQ7S	Strong	Biomarker	[2]
H3-4	OTY6ITYF	Strong	Biomarker	[2]
HS3ST6	OTGSRHS4	Strong	Biomarker	[2]
IL27RA	OTSQBAKI	Strong	Biomarker	[2]
LAMB1	OT6J9LJR	Strong	Genetic Variation	[4]
OVGP1	OTL2W9M5	Strong	Biomarker	[2]
TMPRSS3	OT0GTO1Z	Strong	Biomarker	[2]
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⏷ Show the Full List of 8 DOT(s)

References

1	Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study.Occup Environ Med. 2019 Mar;76(3):169-174. doi: 10.1136/oemed-2018-105545. Epub 2019 Jan 23.
2	Pathway analysis for a genome-wide association study of pneumoconiosis.Toxicol Lett. 2015 Jan 5;232(1):284-92. doi: 10.1016/j.toxlet.2014.10.028. Epub 2014 Nov 4.
3	Associations of IL-4, IL-4R, and IL-13 gene polymorphisms in coal workers' pneumoconiosis in China: a case-control study.PLoS One. 2011;6(8):e22624. doi: 10.1371/journal.pone.0022624. Epub 2011 Aug 3.
4	The association of LAMB1 polymorphism and expression changes with the risk of coal workers' pneumoconiosis.Environ Toxicol. 2017 Sep;32(9):2182-2190. doi: 10.1002/tox.22431. Epub 2017 Apr 26.