Details of Disease

General Information of Disease (ID: DISSN548)

• Disease Name: Pharyngitis
• Synonyms: pharyngitis - acute; persistent sore throat; chronic sore throat; chronic pharyngitis and nasopharyngitis; chronic pharyngitis; chronic pharyn/nasopharyngitis; acute sore throat; acute pharyngitis; Sore throat - chronic; pharyngeal disorder; pharyngeal disease; throat inflammation; inflammation of throat; inflamed throat; Sore throat
• Disease Class: CA02: Acute pharyngitis
• Definition: Inflammation of the throat most often caused by viral and bacterial infections. Other causes include allergens, chemical substances, and trauma.
• Disease Hierarchy:
  DISWD40R: Disease
  DISXCCJJ: Respiratory tract disease
  DIS184KT: Skin inflammation
  DISSN548: Pharyngitis
• ICD Code:
  ICD-11: ICD-11: CA02.Z
  ICD-10: ICD-10: J31.2
  Expand ICD-11: 'CA09.2
  Expand ICD-10: 'J31.2
• Disease Identifiers:
  MONDO ID: MONDO_0002258
  MESH ID: D010612
  UMLS CUI: C0031350
  MedGen ID: 45846
  HPO ID: HP:0025439
  SNOMED CT ID: 405737000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 5 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ZP-005	DM6X8J8	Investigative	NA	[1]
ZP-006	DMWUFTT	Investigative	NA	[1]
ZP-007	DMXO7RG	Investigative	NA	[1]
ZP-008	DMAZT66	Investigative	NA	[1]
ZP-009	DMXA9BW	Investigative	NA	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RHD	TTLCKI8	moderate	Biomarker	[2]

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC9A6	DTN0JXW	moderate	Biomarker	[3]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BATF2	OT4XBZC9	moderate	Biomarker	[4]
SAG	OTDNS3ZQ	moderate	Genetic Variation	[5]
SUMF2	OT37I8JL	moderate	Genetic Variation	[6]
MYOM2	OTD2UOXW	Strong	Biomarker	[7]
NLRP12	OTGR132Z	Strong	Biomarker	[8]

References

• [1] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [2] Immune response against M protein-conserved region peptides from prevalent group A Streptococcus in a North Indian population.J Microbiol Immunol Infect. 2016 Jun;49(3):352-8. doi: 10.1016/j.jmii.2014.05.008. Epub 2014 Jul 30.
• [3] In Vitro and In Vivo Biofilm Characterization of Methicillin-Resistant Staphylococcus aureus from Patients Associated with Pharyngitis Infection.Biomed Res Int. 2016;2016:1289157. doi: 10.1155/2016/1289157. Epub 2016 Sep 28.
• [4] Validity of clinical case definitions for influenza surveillance among hospitalized patients: results from a rural community in North India.Influenza Other Respir Viruses. 2013 May;7(3):321-9. doi: 10.1111/j.1750-2659.2012.00401.x. Epub 2012 Jul 16.
• [5] Molecular analysis of Streptococcus pyogenes strains isolated from Chinese children with pharyngitis.Diagn Microbiol Infect Dis. 2011 Feb;69(2):117-22. doi: 10.1016/j.diagmicrobio.2010.09.011.
• [6] Emergence of high-level fluoroquinolone resistance in emm6 Streptococcus pyogenes and in vitro resistance selection with ciprofloxacin, levofloxacin and moxifloxacin.J Antimicrob Chemother. 2009 May;63(5):886-94. doi: 10.1093/jac/dkp057. Epub 2009 Mar 11.
• [7] Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease.PLoS Negl Trop Dis. 2019 Jul 3;13(7):e0007511. doi: 10.1371/journal.pntd.0007511. eCollection 2019 Jul.
• [8] Phenotypes and genotypes of Chinese adult patients with systemic autoinflammatory diseases.Semin Arthritis Rheum. 2019 Dec;49(3):446-452. doi: 10.1016/j.semarthrit.2019.05.002. Epub 2019 May 11.