Details of Disease | DrugMAP

General Information of Disease (ID: DISSTE29)

Disease Name	Adenocarcinoma in situ
Synonyms	AIS; adenocarcinoma in situ
Definition	A lesion in which the normally situated glands are partially or completely replaced by atypical cells with malignant characteristics.
Disease Hierarchy	DIS13V4C: In situ carcinoma DIS3IHTY: Adenocarcinoma DISSTE29: Adenocarcinoma in situ
Disease Identifiers	MONDO ID MONDO_0003218 MESH ID D065311 UMLS CUI C0334276 MedGen ID 87203 SNOMED CT ID 51642000

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
EML4	TT92GY4	Limited	Biomarker	[1]
USP8	TT1J07C	Strong	Altered Expression	[2]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SAMD14	OTLDQW51	Limited	Posttranslational Modification	[3]
MRPS30	OTDXIAGG	Strong	Biomarker	[4]
MTPAP	OT6HQ02S	Strong	Biomarker	[4]
OCIAD2	OTSWB4SZ	Strong	Altered Expression	[5]
PAPOLA	OTPHD65D	Strong	Biomarker	[4]
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References

1	A case of synchronous bilateral lung cancers: EML4-ALK positive adenocarcinoma in the right lung and adenocarcinoma in situ (the former bronchioloalveolar carcinoma) in the left lung.BMC Pulm Med. 2013 Apr 25;13:25. doi: 10.1186/1471-2466-13-25.
2	Ubiquitin-specific protease 8 is a novel prognostic marker in early-stage lung adenocarcinoma.Pathol Int. 2017 Jun;67(6):292-301. doi: 10.1111/pin.12546. Epub 2017 May 19.
3	Frequent aberrant methylation of the promoter region of sterile alpha motif domain 14 in pulmonary adenocarcinoma.Cancer Sci. 2008 Nov;99(11):2177-84. doi: 10.1111/j.1349-7006.2008.00965.x. Epub 2008 Sep 22.
4	Human papillomavirus (HPV) test and PAP smear as predictors of outcome in conservatively treated adenocarcinoma in situ (AIS) of the uterine cervix.Gynecol Oncol. 2007 Jul;106(1):170-6. doi: 10.1016/j.ygyno.2007.03.016. Epub 2007 May 4.
5	High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma.Pathol Int. 2018 Nov;68(11):596-604. doi: 10.1111/pin.12724. Epub 2018 Oct 15.