Details of Disease

General Information of Disease (ID: DIST148I)

• Disease Name: Intermittent explosive disorder
• Synonyms: explosive personality disorder
• Disease Class: 6C73: Intermittent explosive disorder
• Definition: A disorder characterized by recurrent episodes of serious assaultive acts or destruction of property due to a failure to resist aggressive impulses; the degree of aggression during these episodes is grossly out of proportion to any psychosocial provocation. The aggressive episodes are not etiologically linked to another mental disorder, a general medical condition, or substance use.
• Disease Hierarchy:
  DISRIYJ5: Impulse control disorder
  DIST148I: Intermittent explosive disorder
• ICD Code: ICD-11: ICD-11: 6C73
• Disease Identifiers:
  MONDO ID: MONDO_0001521
  MESH ID: D007174
  UMLS CUI: C0021776
  MedGen ID: 7116
  SNOMED CT ID: 40987004

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SRX246	DMKOTUJ	Phase 2	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DRD2	TTEX248	Strong	Biomarker	[2]
DRD3	TT4C8EA	Strong	Biomarker	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FOSB	OTW6C05J	Strong	Biomarker	[3]

References

• [1] ClinicalTrials.gov (NCT02055638) Safety, Tolerability and Activity of SRX246 in Adults With Intermittent Explosive Disorder (AVN009). U.S. National Institutes of Health.
• [2] Dopaminergic network differences in human impulsivity.Science. 2010 Jul 30;329(5991):532. doi: 10.1126/science.1185778.
• [3] Increased impulsivity during withdrawal from cocaine self-administration: role for DeltaFosB in the orbitofrontal cortex.Cereb Cortex. 2009 Feb;19(2):435-44. doi: 10.1093/cercor/bhn094. Epub 2008 Jun 6.