Details of Disease

General Information of Disease (ID: DISTLZ8K)

Disease Name	Necrotizing soft tissue infection
Synonyms	NSTI
Disease Class	1B71: Necrotising fasciitis
Disease Hierarchy	DIS5QJ9S: Bacterial infection DISTLZ8K: Necrotizing soft tissue infection
ICD Code	ICD-11 ICD-11: 1B71 ICD-10 ICD-10: M72.6
Disease Identifiers	MONDO ID MONDO_0018602 UMLS CUI C2732890 MedGen ID 752585 Orphanet ID 440368 SNOMED CT ID 443928008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AB-103	DMPDQ8T	Phase 3	Small molecular drug	[1]
Reltecimod	DM49WQQ	Phase 3	Peptide	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PAGR1	OTXR5PQ8	Strong	Biomarker	[3]
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References

1	ClinicalTrials.gov (NCT02469857) Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections.
2	ClinicalTrials.gov (NCT03403751) Phase 3 Study of Reltecimod vs Placebo in Patients With Sepsis-associated Acute Kidney Injury. U.S. National Institutes of Health.
3	Necrotizing soft tissue infections caused by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis of groups C and G in western Norway.Clin Microbiol Infect. 2013 Dec;19(12):E545-50. doi: 10.1111/1469-0691.12276. Epub 2013 Jun 25.