Details of Disease | DrugMAP

General Information of Disease (ID: DISTSFJZ)

Disease Name	Obsolete isolated scaphocephaly
Synonyms	isolated dolichocephaly; non-syndromic sagittal synostosis
Definition	OBSOLETE. Isolated scaphocephaly is a form of nonsyndromic craniosynostosis characterized by premature fusion of the sagittal suture.
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DISTSFJZ: Obsolete isolated scaphocephaly

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
TWIST1	OTB3H60O	Supportive	Autosomal dominant	[1]
ERF	OTGTA85X	Supportive	Autosomal dominant	[2]
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This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ERF	TTGXULC	Supportive	Autosomal dominant	[2]
TWIST1	TTX1MY7	Supportive	Autosomal dominant	[1]
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References

1	Isolated sagittal and coronal craniosynostosis associated with TWIST box mutations. Am J Med Genet A. 2007 Apr 1;143A(7):678-86. doi: 10.1002/ajmg.a.31630.
2	Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis. Nat Genet. 2013 Mar;45(3):308-13. doi: 10.1038/ng.2539. Epub 2013 Jan 27.