Details of Disease

General Information of Disease (ID: DISUYSBZ)

• Disease Name: Adenovirus infection
• Synonyms: Adenoviridae infection; disease caused by adenovirus; infections, Adenoviridae; adenovirus infections; infection, Adenoviridae; infections, adenovirus; infection, adenovirus; Adenoviridae disease or disorder; adenovirus infection; Adenoviridae infectious disease; Adenoviridae caused disease or disorder; disease due to adenovirus; adenoviridae infectious disease
• Disease Class: 1A20: Adenovirus enteritis
• Definition: An infectious process caused by adenovirus. The virus may cause respiratory illness, conjunctivitis, gastroenteritis, and cystitis.|Editor note: check adenovirus vs adenoviridae
• Disease Hierarchy:
  DISDI77C: Primary viral infectious disease
  DISEM33Q: Infectious disease
  DISUYSBZ: Adenovirus infection
• ICD Code:
  ICD-11: ICD-11: 1A20
  ICD-10: ICD-10: B34.0
  Expand ICD-11: '1D90
  Expand ICD-10: 'B34.0
• Disease Identifiers:
  MONDO ID: MONDO_0043479
  MESH ID: D000257
  UMLS CUI: C0001486
  MedGen ID: 1754
  SNOMED CT ID: 25225006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
DR-5001	DMS5TMK	Phase 3	NA	[1]
PXVX0047	DM3PILA	Phase 1	NA	[2]
Viralym-A	DMWQR2V	Phase 1	Cell therapy	[3]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ADAMTS5	TTXSU2Y	Limited	Altered Expression	[4]
EIF4EBP2	TTNBTCW	moderate	Altered Expression	[5]
MAP4	TT0VFPN	moderate	Biomarker	[6]
CHKA	TT10AWB	Strong	Altered Expression	[7]
DHFR	TTYZVDJ	Strong	Altered Expression	[8]

This Disease Is Related to 31 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
HBS1L	OTA3U1N6	Limited	Altered Expression	[9]
TAFA5	OT2SWBT6	Limited	Altered Expression	[10]
BCKDHB	OT8OSVYU	moderate	Biomarker	[11]
C1QC	OTLE5U1P	moderate	Biomarker	[12]
CACUL1	OT6P1ZVP	moderate	Biomarker	[13]
CALD1	OTNJKJ6Q	moderate	Biomarker	[14]
CNKSR3	OTXP4QH8	moderate	Biomarker	[15]
CNOT3	OT4D5Z9L	moderate	Altered Expression	[16]
CNOT7	OTJBKCPI	moderate	Altered Expression	[16]
DEFA1	OT5N1B9B	moderate	Altered Expression	[17]
DSG2	OTJPB2TO	moderate	Biomarker	[18]
GFM1	OTUN4V3N	moderate	Altered Expression	[19]
HNRNPUL1	OTJP4U7K	moderate	Altered Expression	[20]
ITGB5	OT21MF51	moderate	Biomarker	[21]
MAGI1	OTMV4ASV	moderate	Biomarker	[15]
MARCO	OT0NW2Q0	moderate	Biomarker	[22]
MYO5A	OTMWLP3E	moderate	Altered Expression	[23]
MYO6	OTJQYRC7	moderate	Altered Expression	[23]
NFATC4	OTTDCUAO	moderate	Altered Expression	[24]
NRIP1	OTIZOJQV	moderate	Altered Expression	[25]
OBP2A	OTBIJ5TI	moderate	Biomarker	[26]
PLA2G10	OTRZ2L5A	moderate	Biomarker	[27]
PLA2G2D	OTU604XM	moderate	Biomarker	[27]
SEPTIN1	OT4GVSU3	moderate	Biomarker	[28]
SMARCAL1	OTTKXLUZ	moderate	Biomarker	[13]
TNKS1BP1	OTBIZECQ	moderate	Altered Expression	[16]
TRPS1	OT7XPPEL	moderate	Biomarker	[29]
CLEC5A	OT19WV30	Strong	Biomarker	[30]
EIF2S1	OTM0GDTP	Strong	Posttranslational Modification	[31]
MATK	OTVOJJLJ	Strong	Altered Expression	[7]
PLEKHO1	OTMVUQ9W	Strong	Altered Expression	[32]

References

• [1] ClinicalTrials.gov (NCT00382408) A Clinical Trial to Evaluate the Safety, Efficacy, and Immunogenicity of DR-5001. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] ClinicalTrials.gov (NCT02276820) Most Closely Human Leukocyte Antigen (HLA)-Matched Adenovirus-specific T Lymphocytes (Viralym-A). U.S. National Institutes of Health.
• [4] Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5.FASEB J. 2019 Jan;33(1):619-630. doi: 10.1096/fj.201800259R. Epub 2018 Jul 17.
• [5] Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2.Virology. 1997 Oct 13;237(1):182-6. doi: 10.1006/viro.1997.8757.
• [6] Microtubule-dependent distribution of mRNA in adult cardiocytes.Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1135-44. doi: 10.1152/ajpheart.01275.2007. Epub 2008 Jan 4.
• [7] Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors.Cancer. 2004 Sep 1;101(5):1018-27. doi: 10.1002/cncr.20442.
• [8] Posttranscriptional control of DHFR gene expression during adenovirus 2 infection.J Virol. 1985 Apr;54(1):72-7. doi: 10.1128/JVI.54.1.72-77.1985.
• [9] Cooperative binding of EF-1A to the E1A enhancer region mediates synergistic effects on E1A transcription during adenovirus infection.J Virol. 1991 Sep;65(9):5084-7. doi: 10.1128/JVI.65.9.5084-5087.1991.
• [10] Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury Through Sphingosine-1-Phosphate Receptor 2.Circulation. 2018 Jul 3;138(1):48-63. doi: 10.1161/CIRCULATIONAHA.117.032398. Epub 2018 Feb 16.
• [11] p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: suppression by E1B 19K and Bcl-2 proteins.Cell Growth Differ. 1995 Feb;6(2):131-7.
• [12] Complement component C1q and anti-hexon antibody mediate adenovirus infection of a CAR-negative cell line.Viral Immunol. 2008 Dec;21(4):469-76. doi: 10.1089/vim.2008.0032.
• [13] Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication.J Virol. 2019 Jun 14;93(13):e00402-19. doi: 10.1128/JVI.00402-19. Print 2019 Jul 1.
• [14] Gene delivery of l-caldesmon protects cytoskeletal cell membrane integrity against adenovirus infection independently of myosin ATPase and actin assembly.Am J Physiol Cell Physiol. 2004 Oct;287(4):C1125-38. doi: 10.1152/ajpcell.00530.2003. Epub 2004 Jun 9.
• [15] The PDZ1 and PDZ3 domains of MAGI-1 regulate the eight-exon isoform of the coxsackievirus and adenovirus receptor.J Virol. 2012 Sep;86(17):9244-54. doi: 10.1128/JVI.01138-12. Epub 2012 Jun 20.
• [16] Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.J Virol. 2018 May 29;92(12):e02034-17. doi: 10.1128/JVI.02034-17. Print 2018 Jun 15.
• [17] Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection.Can Respir J. 2018 Jul 31;2018:1038593. doi: 10.1155/2018/1038593. eCollection 2018.
• [18] Two types of functionally distinct fiber containing structural protein complexes are produced during infection of adenovirus serotype 5.PLoS One. 2015 Feb 27;10(2):e0117976. doi: 10.1371/journal.pone.0117976. eCollection 2015.
• [19] Noninvasive imaging of transcriptionally restricted transgene expression following intratumoral injection of an adenovirus in which the COX-2 promoter drives a reporter gene.Mol Imaging Biol. 2004 Nov-Dec;6(6):395-404. doi: 10.1016/j.mibio.2004.09.002.
• [20] A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.J Virol. 2008 Aug;82(15):7640-52. doi: 10.1128/JVI.00170-08. Epub 2008 May 14.
• [21] Role of genetic susceptibility to latent adenoviral infection and decreased lung function.Respir Med. 2009 Nov;103(11):1672-80. doi: 10.1016/j.rmed.2009.05.008. Epub 2009 Jun 6.
• [22] Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.mBio. 2017 Aug 1;8(4):e00670-17. doi: 10.1128/mBio.00670-17.
• [23] Nuclear actin and myosins in adenovirus infection.Exp Cell Res. 2015 Nov 1;338(2):170-82. doi: 10.1016/j.yexcr.2015.07.025. Epub 2015 Jul 27.
• [24] SIRT6 Suppresses NFATc4 Expression and Activation in Cardiomyocyte Hypertrophy.Front Pharmacol. 2019 Jan 8;9:1519. doi: 10.3389/fphar.2018.01519. eCollection 2018.
• [25] Receptor-interacting Protein 140 represses Sirtuin 3 to facilitate hypertrophy, mitochondrial dysfunction and energy metabolic dysfunction in cardiomyocytes.Acta Physiol (Oxf). 2017 May;220(1):58-71. doi: 10.1111/apha.12800. Epub 2016 Oct 12.
• [26] Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging.J Cell Biochem. 2017 Nov;118(11):3635-3642. doi: 10.1002/jcb.25593. Epub 2017 Jul 31.
• [27] Human group III phospholipase A2 suppresses adenovirus infection into host cells. Evidence that group III, V and X phospholipase A2s act on distinct cellular phospholipid molecular species.Biochim Biophys Acta. 2007 Nov;1771(11):1389-96. doi: 10.1016/j.bbalip.2007.09.006. Epub 2007 Oct 10.
• [28] Molecular monitoring of adenovirus reactivation in faeces after haematopoietic stem-cell transplantation to predict systemic infection: a retrospective cohort study.Lancet Haematol. 2018 Sep;5(9):e422-e429. doi: 10.1016/S2352-3026(18)30130-3.
• [29] Trps1 regulates biliary epithelial-mesenchymal transition and has roles during biliary fibrosis in liver grafts: a preliminary study.PLoS One. 2015 Apr 17;10(4):e0123233. doi: 10.1371/journal.pone.0123233. eCollection 2015.
• [30] The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival.J Transl Med. 2017 Nov 10;15(1):234. doi: 10.1186/s12967-017-1336-z.
• [31] Adenovirus inhibition of cellular protein synthesis is prevented by the drug 2-aminopurine.Proc Natl Acad Sci U S A. 1990 Sep;87(18):7115-9. doi: 10.1073/pnas.87.18.7115.
• [32] CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys.Free Radic Biol Med. 2018 Feb 1;115:338-350. doi: 10.1016/j.freeradbiomed.2017.12.013. Epub 2017 Dec 14.